Right Brain: We were all once "fixed and dilated"

All adults once were children.

All adults once were children, and children exposed to unrelenting adversities or toxic stress are at risk for developing a multitude of health conditions that threaten their development and eventual adult health status. Pediatricians and their pediatric surgeon colleagues can help families and their children develop resiliency by properly addressing the needs of families and their children and...

We were all young once: an intragenomic perspective on parent-offspring conflict.

Parent-offspring conflict (POC) describes the evolutionary conflict between offspring and their parents over parental resource allocation. Offspring are expected to demand more resources than their parents are willing to supply because these offspring are more related to their own than to their siblings' offspring. Kin selection acts to limit these divergent interests. Our model departs from pr...

Once there were twenty.

Aminoacyl-tRNA synthetases play a central role in protein synthesis by covalently linking the correct amino acid to the correct tRNA (1). Each aminoacyl-tRNA is then carried to the ribosome where it interacts with the cognate trinucleotide codon on the mRNA and transfers the amino acid onto a growing polypeptide chain. Work on tRNAs and aminoacyltRNA synthetases from bacteria, fungi, plants, an...

Proteomics in asthma: the clinicians were right after all, were not they?

Clinical disease phenotypes with underlying information of molecular and biological signatures for the same, is a prerequisite for improving medical care and developing more effective, stratified management strategies. This commentary reviews the research carried out by Cao et al. to unravel biological networks associated with different clinical categories of asthma. It finally comments on the ...

Are We Asking All the Right Questions About Quality of Care in Low- and Middle-Income Countries?